HIV/AIDS Vaccine Development
DNA vaccines expressing SIV antigens decrease viremia upon challenge
Published in AIDS Weekly, September 19th, 2005
"We have tested the efficacy of DNA immunization as a single vaccination modality for rhesus macaques followed by highly pathogenic SIVmac251 challenge. To further improve immunogenicity of the native proteins, we generated expression vectors producing fusion of the proteins Gag and Env to the secreted chemokine MCP3, targeting the viral proteins to the secretory pathway and to a beta-catenin (CATE) peptide, targeting the viral proteins to the intracellular degradation pathway," researchers in the United States report.
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Source: AIDS Weekly (2005-09-19)
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