HIV/AIDS Pathogenesis
HIV Nef establishes superinfection immunity by downregulating CCR5 and CD4
Published in AIDS Weekly, September 26th, 2005
"Viruses frequently render cells refractory to subsequent infection with the same virus. This state of superinfection immunity counteracts potentially detrimental consequences for the infected cell and facilitates high-level replication and viral spread in the host.
"Here, we show that human immunodeficiency virus (HIV) employs its early gene product Nef to efficiently interfere with superinfection at the viral-entry step," investigators in Germany report.
"In this context," said the authors, "we identify the downregulation of cell-surface CCR5, the major...
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Source: AIDS Weekly (2005-09-26)
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