HIV/AIDS Pathogenesis
SDF-1 3'A allele increases risk of progression to AIDS
Published in AIDS Weekly, September 26th, 2005
In a recent report, researchers in the Netherlands conducted a study "to investigate the causal pathways by which age and the CCR5-Delta32, CCR2-64I and SDF-1 3'A alleles influence progression to AIDS." Follow-up "data from 2 cohort studies among homosexual men (n=400), having >10 years of follow-up" were analyzed.
"The effects of the 4 cofactors on the CD4 and HIV-1 RNA trajectories after seroconversion were modeled in a random-effects model. A proportional hazards model was used to investigate their effect on the risk of AIDS after correction for CD4 cell count and RNA level.
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Source: AIDS Weekly (2005-09-26)
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