HIV/AIDS-Tuberculosis Coinfection

Elevated CCR5/CXCR4/cytokines persistently increase viral load in TB coinfection

Published in AIDS Weekly, September 26th, 2005

Increased CCR5 and CXCR4 expression plus elevated cytokine levels lead to persistently elevated HIV viremia in tuberculosis coinfected patients.

According to recent research from Ethiopia, "The pathogenesis of persistently elevated plasma HIV viremia in patients coinfected with tuberculosis (TB) during anti-TB treatment in Africans remains unknown.

"We examined the expression of chemokine receptors CCR5 and CXCR4 on CD4+ T cells and plasma chemokine levels of macrophage inflammatory protein (MIP)-1alpha, MIP-1beta, regulated on activation normal T expressed and secreted (RANTES), and stromal cell-derived factor (SDF)-1alpha among TB patients with HIV...

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Source: AIDS Weekly (2005-09-26)

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