HIV/AIDS Pathogenesis
HIV-1 Vpr impairs dendritic cell maturation and T cell activation
Published in AIDS Weekly, October 3rd, 2005
According to recent research from the United States, "Antigen presentation and T-cell activation are dynamic processes involving signaling molecules present in both APCs and T cells. Effective APC function and T-cell activation can be compromised by viral immune evasion strategies, including those of human immunodeficiency virus type 1 (HIV-1).
"In this study, we determined the effects of HIV-1 Vpr on one of the initial target of the virus, dendritic cells (DC), by investigating DC maturation, cytokine profiling, and CD8-specific T-cell stimulation function followed by a second...
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Source: AIDS Weekly (2005-10-03)
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