HIV/AIDS Pathogenesis
Ubiquitylation of Cdk9 By Skp2 facilitates optimal HIV-1 Tat transactivation
Published in AIDS Weekly, October 3rd, 2005
According to a study from the United States, "By recruiting the positive transcriptional elongation factor b (P-TEFb) to paused RNA polymerase II, the transactivator Tat stimulates transcriptional elongation of the human immunodeficiency virus type 1 (HIV-1) genome.
"We found that cyclin-dependent kinase 9 (Cdk9), the catalytic subunit of P-TEFb, is ubiquitylated in vivo. This ubiquitylation depended on the Skp1, Cul1, and F-box protein E3 ubiquitin ligase Skp2."
"Likewise," said the authors, "Tat required Skp2 since its transactivation of the...
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Source: AIDS Weekly (2005-10-03)
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