Published in AIDS Weekly, October 17th, 2005
"The tripartite motif 5 alpha protein (TRIM5 alpha) is one of several factors expressed by mammalian cells that inhibit retrovirus replication. Human TRIM5 alpha (huTRIM5 alpha) inhibits infection by N-tropic murine leukemia virus (N-MLV) but is inactive against human immunodeficiency virus type 1 (HIV-1).
"However, we show that replacement of a small segment in the carboxy-terminal B30.2/SPRY domain of huTRIM5a with its rhesus macaque counterpart (rhTRIM5 alpha) endows it with the ability to potently inhibit HIV-1 infection," scientists in the United States...
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