HIV/AIDS Viral Restriction
TRIM5 alpha domains responsible for HIV-1 restriction activity and specificity
Published in AIDS Weekly, October 17th, 2005
"The tripartite motif 5 alpha protein (TRIM5 alpha) is one of several factors expressed by mammalian cells that inhibit retrovirus replication. Human TRIM5 alpha (huTRIM5 alpha) inhibits infection by N-tropic murine leukemia virus (N-MLV) but is inactive against human immunodeficiency virus type 1 (HIV-1).
"However, we show that replacement of a small segment in the carboxy-terminal B30.2/SPRY domain of huTRIM5a with its rhesus macaque counterpart (rhTRIM5 alpha) endows it with the ability to potently inhibit HIV-1 infection," scientists in the United States...
Want to see the full article?
We're a pay-per-view site for premium content. If you'd like to purchase this article, it's only $3.00.
Welcome to NewsRx!
Learn more about a six-week, no-risk free trial of AIDS Weekly
Source: AIDS Weekly (2005-10-17)
More Articles from AIDS Weekly
- HIV/AIDS Diagnostics
Microchip CD4 counting method monitors HIV in resource-poor settings - HIV/AIDS Epidemiology
HIV-1 group M isolates are 100-fold-more fit than group 0 or HIV-2 strains - HIV/AIDS Pathogenesis
CD4+CD25+ regulatory T cells crucial in HIV infection - HIV/AIDS Transmission
Cervicovaginal lavage fluid contains an inhibitor of HIV binding to DC-SIGN - HIV/AIDS Treatment
HDAC inhibitor plus HAART accelerates HIV clearance from resting CD4+ cells - Adverse Drug Reaction
GSK makes changes to the development program for ONO-4128/873140 - More from this issue of AIDS Weekly
NewsRx is Social
Follow us on your favorite social network by clicking on a button below:
Top Medical Newsletters
Awards
Best Health/Healthcare Content, 2012
Best Health/Healthcare Content, 2011
Best e-Business Site, 2010
Best e-Business Site, 2009
Best e-Business Site, 2008
Best e-Business Site, 2007
Best e-Business Site, 2006
Best Healthcare Content, 2005
Best Overall Internet Site, 2005
Best Interactive Site, 2005
Facts & Stats
NewsRx also is available at LexisNexis, Gale, ProQuest, Factiva, Dialog, Thomson Reuters, NewsEdge, and Dow Jones.
- Google 2010 PageRank: #2 Among Top Health News and Media Publications
- Google 2010 PageRank: #2 Among Top Science Publications in Biology/Physiology
- Google 2010 PageRank: #2 Among Top News and Media for the Business of Pharmaceuticals
- Amazon's Alexa 2010 PageRank: #2 News and Media Site for the Pharmaceutical Industry
