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HIV/AIDS Diagnostics

HIV reverse transcriptase activity correlates with HIV RNA load

Published in AIDS Weekly, October 24th, 2005

HIV reverse transcriptase activity correlates with HIV RNA load.

According to a study from the United States, "Measurement of human immunodeficiency virus type 1 (HIV-1) plasma RNA levels using Roche AMPLICOR version 1.5 (HIV RNA) is an integral part of monitoring HIV-infected patients in industrialized countries. These assays are currently unaffordable in resource-limited settings."

"We investigated a reverse transcriptase (RT) assay as a less expensive alternative for measuring viral burden that quantifies RT enzyme activity in clinical plasma samples.

"A comparison of RT and HIV RNA assays was performed on 29 paired plasma...

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