HIV/AIDS Immunity
Low-level antigen exposure is sufficient for sustained HIV-specific immunity
Published in AIDS Weekly, October 24th, 2005
According to a study from the Netherlands, "Long-term nonprogressive HIV infection, characterized by low but detectable viral load and stable CD4 counts in the absence of antiviral therapy, is observed in about 5% of HIV-infected patients.
"Here we identified four therapy naive individuals who are strongly seropositive for HIV-1 but who lack evidence of detectable HIV p24 antigen, plasma RNA, and proviral DNA in routine diagnostic testing."
"With an ultrasensitive PCR, we established that frequencies of pol proviral DNA sequences were as low as 0.2-0.5...
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Source: AIDS Weekly (2005-10-24)
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