HIV/AIDS Vaccine Development
Macaque MHC class I allele Mane-A*10 presents immunodominant SIV Gag epitope
Published in AIDS Weekly, October 24th, 2005
According to a study from Australia and the United States, "The pigtail macaque (Macaca nemestrina) is a common model for the study of AIDS. The pigtail major histocompatibility complex class I allele Mane-A*10 restricts an immunodominant simian immunodeficiency virus (SIV) Gag epitope (KP9) which rapidly mutates to escape T cell recognition following acute simian/human P immunodeficiency virus infection."
"Two technologies for the detection of Mane-A*10 in outbred pigtail macaques were developed: reference strand-mediated conformational analysis and...
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Source: AIDS Weekly (2005-10-24)
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