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AIDS Weekly

Susan Hasty, Publisher

Table of Contents . . . November 7th, 2005

Non-Subscriber - Summaries Only

Related Areas: Other Issues in AIDS Weekly | Other Publications

HIV/AIDS Drug Development - Genetically engineered live bacteria block HIV fusion and entry

HIV/AIDS Drug Development - Plant extract scutellarin inhibits HIV-1 RT, particle attachment and cell fusion

HIV/AIDS Pathogenesis - CCR5+CD4+ cells highly activated during primary HIV-1 infection

HIV/AIDS Prevention - HAART reduces transmission risk between HIV-discordant heterosexual couples

HIV/AIDS Viral Inhibitor - NNRTI UC-781 inhibits HIV-1 infection of cervical tissue when applied as a vaginal microbicide

Business & Finance - Bio lab company, CLS join to integrate bioanalytical, genotyping, biostorage services

Clinical Trials - Clinical trial of antiviral HIV/AIDS therapeutic in HIV-positive patients initiated

Disease Control - Tuberculosis poses a risk to a pregnant woman and her fetus

Drug Development - Cidofovir lipid ester analogs inhibit herpesvirus replication

Drug Development - Novel high-throughput screening assays identify HIV integrase strand transfer inhibitors

Facilities - U.S. Centers for Disease Control and Prevention completes $165 million facility

Finance - Development of VivaGel accelerated with US$20M funding from U.S. National Institutes of Health

HIV-Associated Cancer - Rituximab added to CHOP does not improve clinical outcome of HIV-associated non-Hodgkin lymphoma

HIV/AIDS Behavioral Medicine - Behavior change models precipitate AIDS risk reduction in sub-Saharan Africa

HIV/AIDS Coinfection - Intestinal helminth treatment does not reduce plasma HIV-1 RNA in coinfected patients

HIV/AIDS Diagnostics - High-throughput HIV-1 full replication assay includes Vif as an antiviral target

HIV/AIDS Diagnostics - Molecular tests company investigating collaboration for testing blood samples

HIV/AIDS Diagnostics - Sensitivity and specificity of rapid HIV test compared with fourth-generation ELISA

HIV/AIDS Drug Development - p73 interacts with HIV-1 Tat in astrocytic cells and prevents its acetylation on lysine 28

HIV/AIDS Drug Resistance - Drug-resistant HIV-1 variants most commonly seen in patients infected with subtype B virus

HIV/AIDS Epidemiology - HIV epidemic increased infection-related hospital admissions in rural South Africa

HIV/AIDS HAART - Amprenavir significantly lowers plasma atazanavir levels when given in combination

HIV/AIDS HAART - Mortality and morbidity from advanced AIDS has declined in Hong Kong in HAART era

HIV/AIDS HAART - Rate of virologic suppression is low among HIV-infected children on HAART

HIV/AIDS HAART - Risk of acquiring drug resistant HIV mutations is low for patients on HAART with detectable viremia

HIV/AIDS Healthcare Access - Many HIV-infected adults perceive discrimination by health care providers

HIV/AIDS Pathogenesis - Simian immunodeficiency virus disrupts extended lengths of the blood-brain barrier

HIV/AIDS Pathogenesis - Virus attachment and replication promoted after HIV-1 acquires host CD28 and CD152

HIV/AIDS Prevention - Arizona health leaders discuss new methods for protecting women from HIV

HIV/AIDS Prevention - Gains in condom use offset by increases in the number of sex partners in Uganda

HIV/AIDS Prognosis - Circulating dendritic cells correlate inversely with HIV RNA and positively with CD4 cell counts

HIV/AIDS Risk Factors - Requiring help injecting predicts HIV infection incident among intravenous drug users

HIV/AIDS Risk Factors - Study explores importance of relationship factors and safer sex practices

HIV/AIDS Therapy - AIDS clinical trials group quality-of-life scores estimated

HIV/AIDS Therapy - Antioxidant therapy may control protease inhibitor-associated cardiovascular complications

HIV/AIDS Therapy - Inappropriate drug combinations in HIV/AIDS increase side effects risk, may decrease drug efficacy

HIV/AIDS Transmission - Planned caesarian section is safe and effective for preventing transmission of HIV

HIV/AIDS Vaccine - Differential restriction of HIV-2 and SIVmac by TRIM5 alleles studied

HIV/AIDS Vaccine - HIV vectors and molecular clones have similar neutralization phenotype

HIV/AIDS Vaccine - In-depth analysis of heterosexual HIV-1 superinfection reported

HIV/AIDS Vaccine - Interleukin-12 enhances CD8 SIV vaccine immune response

HIV/AIDS Vaccine - Racial/ethnic minorities increasing in government-funded networks of U.S. HIV vaccine trials

HIV/AIDS Vaccine - Standardization of nonhuman primate models needed to assess AIDS vaccines

HIV/AIDS Wasting Syndrome - Risk of {{>=}}5% unintentional weight loss in HIV-infected patients is increasing

HIV/AIDS-Malaria Coinfection - HIV-1 RNA and CD4 count moderately but inconsistently associated with malaria parasitemia

HIV/AIDS-Malaria Coinfection - No significant interaction found between any malaria category and HIV serostatus

HIV/AIDS-Related Lipodystrophy - Plasminogen activator inhibitor type 1 increased in HIV-associated lipodystrophy

HIV/AIDS-Tuberculosis Coinfection - Management of HIV/tuberculosis coinfection is a high priority in low-income settings

HIV/AIDS-Tuberculosis Coinfection - Recurrent tuberculosis in HIV-infected children common in high-burden TB setting

HIV/AIDS-Tuberculosis Coinfection - Tuberculosis treatment outcome is worse in HIV-infected patients

Hematology - Patient host factors prevent GB virus C, hepatitis, and HIV infection in exposed hemophiliacs

Hepatitis C Treatment - Latin Americans with chronic hepatitis C are less likely to initiate or continue therapy

Infectious Diseases - Clinical malaria increase attributable to HIV-1 epidemic in sub-Saharan Africa

Malaria Therapy - Drug combination against AIDS-related infections also effective against malaria

Nephrology - HIV fuses to glomerular endothelial cells through an CXCR4-mediated mechanism

Nevirapine - Drug combination suppresses viral replication in HIV/AIDS patients in Nigeria

Pediatrics HIV/AIDS - Immature CD4+ cells in newborn thymus support production of infectious simian-HIV

Quality Assurance - Biotech holding company announces facilities GMP-certified for drug production

Quality Assurance - HIV-infected patients face discrimination from doctors

Re-emerging Infections -  Mycobacterium bovis infections are a re-emerging disease

Tuberculosis - Micronutrient supplementation and zinc do not have significant effects on TB culture conversion

Tuberculosis - Moxifloxacin to be studied as new TB treatment

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