HIV/AIDS Drug Development
Genetically engineered live bacteria block HIV fusion and entry
Published in AIDS Weekly, November 7th, 2005
"Most HIV transmission occurs on the mucosal surfaces of the gastrointestinal and cervicovaginal tracts, both of which are normally coated by a biofilm of nonpathogenic commensal bacteria. We propose to genetically engineer such naturally occurring bacteria to protect against HIV infection by secreting antiviral peptides," scientists in the United States report.
"Here we describe the development and characterization of Nissle 1917, a highly colonizing probiotic strain of Escherichia coli, secreting HIV-gp41-hemolysin A hybrid peptides that block HIV fusion and entry into target...
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Source: AIDS Weekly (2005-11-07)
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