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AIDS Weekly

Susan Hasty, Publisher

Table of Contents . . . November 14th, 2005

Non-Subscriber - Summaries Only

Related Areas: Other Issues in AIDS Weekly | Other Publications

Genetics & Genomics - Genotype combination advantageous in resisting HIV-1 transmission

HIV/AIDS Pathogenesis - HIV-1 variants from single plasma samples have various neutralization sensitivities

HIV/AIDS Prevention - Vaginal microbicide phase III trial underway, 10,000 women to be enrolled

HIV/AIDS Topical Microbicide - Topically applied amphibian-derived antimicrobial peptides inhibit HIV infection

HIV/AIDS-Related Lipodystrophy - Metformin improves lipid profiles in HIV-related lipodystrophy

Awards - Tulane receives millions for international health and tropical medicine research

Bacterial Vaginosis - Amsel criteria poor predictor compared to other diagnositic tests for bacterial vaginosis

Bacteriology -  M. intracellulare infects women increasingly beyond menopause

Behavioral Medicine - Transtheoretical model promotes integrated pregnancy and STD prevention in family planning setting

Blood Safety - Blood screening and vaccines lower the risk of transfusion-transmitted infections in Italy

Business & Finance - Biotech company announces final settlement of 4-year Serostim investigation

HIV/AIDS Pathogenesis - New findings in HIV/AIDS pathogenesis described

Business & Finance - Genetics therapy-focused biotech company completes $30 million financing

Clinical Trials - DNA 'prime-boost' vaccine technology enters phase 2 clinical trial for HIV

Clinical Trials - Phase 2 testing of HIV vaccine developed with Vaccine Research Center initiated

Collaborations - Alliance formed to combat infectious diseases

Dental Research - Study shows HIV-positive and at-risk women tend to avoid dental care

Disease Control - Public opinion supports condom education in Indiana public schools

HIV/AIDS Pathogenesis - Researchers report details of new studies and findings in the area of HIV/AIDS pathogenesis

Drug Development - Intratect approved for nine European countries

Epidemiology - Indigenous Western Australians have greater HIV transmission risk than nonindigenous people

Finance - Virus-focused biopharma company reports Q3 2004 Fuzeon net sales of $48.9 million

Genetics & Genomics - A protein in St. John's wort is found to suppress HIV-1 gene expression

HIV/AIDS Antiretroviral - UC-781 inhibits HIV-1 infection of cervical tissue and dissemination by migratory cells

HIV/AIDS Diagnosis - Reports advance knowledge in HIV/AIDS diagnosis research

HIV/AIDS Diagnostics - Genotypic assay determines all HIV-1 protease and reverse transcriptase subtypes

HIV/AIDS Diagnostics - Rapid test kit increases presence in South Africa; moves into East Africa

HIV/AIDS Diagnostics - Ultrasensitive p24 antigen ELISA diagnoses subtype C HIV-1 infection in infants

HIV/AIDS Drug Development - Covalent stabilization of coiled coils of the HIV gp41 N region inhibits viral infection

HIV/AIDS Drug Development - Pleiotrophin inhibits HIV infection by binding the cell surface-expressed nucleolin

HIV/AIDS Drug Development - Two HIV-1 entry inhibitors prevent gp120 binding to CD4

HIV/AIDS Drug Mutations - HIV RT L74V mutation reduces ATP-dependent removal of ZDV-MP from newly synthesized viral DNA

HIV/AIDS Drug Mutations - Mutations that abrogate HIV-1 RT dimerization affect maturation of the RT heterodimer

HIV/AIDS Drug Resistance - Molecular footprint of drug-selective pressure identified in HIV transmission chain

HIV/AIDS Drug Resistance - Reverse transcriptase inhibitors act together to increase HIV-1 mutation frequencies

HIV/AIDS Epidemiology - HIV prevalence associated with increased intravenous drug use increasing in Mexico

HIV/AIDS Epidemiology - Monte Carlo model estimates the natural variation in HIV infection

HIV/AIDS Exposure - CD91 expression increased on monocytes of exposed yet HIV-1-seronegative persons

HIV/AIDS Neurology - HIV-1 species barrier does not extend to uptake by the blood-brain barrier

HIV/AIDS Pathogenesis - Cul5-E3 ligase is a common pathway hijacked by HIV-1 Vif to defeat h-A3F and h-A3G

HIV/AIDS Pathogenesis - Findings in HIV/AIDS pathogenesis provide new insights

HIV/AIDS Pathogenesis - HIV infection route is a factor in the broad humoral immune response in intravenous drug users

HIV/AIDS Pathogenesis - HIV reactivation by phorbol esters or T-cell receptor ligation requires PKCalpha and PKCtheta

HIV/AIDS Pathogenesis - HIV-1 Nef-induced FasL induction and bystander killing requires p38 MAPK activation

HIV/AIDS Pathogenesis - HLA-A2 downmodulation mechanisms similar in primary T cells and macrophages

HIV/AIDS Pathogenesis - Lipid raft integrity critical for HIV Env and Gag coclustering and virological synapse assembly

HIV/AIDS Pathogenesis - Morphine inhibits anti-HIV activity of CD8+ cells in HIV latently infected cells

HIV/AIDS Pathogenesis - Type I IFN production is profoundly and transiently impaired in primary HIV-1 infection

HIV/AIDS Pathogenesis - Very early in life, HIV-1-specific CTL can select for viral escape variants

HIV/AIDS Pediatrics Research - Decreased bone mass in HIV-infected children due to disease severity and growth delay

HIV/AIDS Prevention - India's HIV/AIDS pandemic threatens economic and social fabric

HIV/AIDS Prognosis - APOBEC3G/CEM15 mRNA levels inversely associated with HIV viremia

HIV/AIDS Prognosis - HLA-B63 is associated with low HIV RNA

HIV/AIDS Research - Procyon announces positive preclinical results for lead HIV protease inhibitor

HIV/AIDS Therapy - AIDS Support Organization opens AIDS counseling and training center in Uganda

HIV/AIDS Therapy - Abacavir/lamivudine/zidovudine improves HAART adherence in HIV-1-infected patients

HIV/AIDS Therapy - HIV protease inhibitor ritonavir increases endothelial monolayer permeability

HIV/AIDS Therapy - Trials comparing therapies for HIV/AIDS, related Kaposi's sarcoma are urgently needed in sub-Saharan Africa

HIV/AIDS Therapy - Updated HIV guidelines support fusion inhibitor plus protease inhibitor therapy

HIV/AIDS Vaccine Development - CD8+ lymphocytes do not protect against acute SIV superinfection

HIV/AIDS Vaccine Development - HIV trials feasible with fewer animals if subjects repeatedly challenged with low doses

HIV/AIDS Vaccine Development - HIV-1 Env clones developed for standardized assessments of vaccine-elicited neutralizing antibodies

HIV/AIDS Vaccine Development - Research collaboration formed to develop topical delivery of therapeutic DNA vaccines

HIV/AIDS-Related Atherosclerosis - HIV-1 Tat induces VCAM-1 expression in pulmonary artery endothelial cells

HIV/AIDS-Related Infection - Incidence of esophageal candidiasis in AIDS patients in Europe is declining

HIV/AIDS-Related Infection - Nocardiosis to be considered in HIV patients with low CD4 counts

HIV/AIDS-Related Infection - Oral lesions are indicators of infection in HIV/AIDS

HIV/AIDS-Related Kaposi Sarcoma - AIDS-Kaposi sarcoma patients treated with HAART have a high clinical response rate

HIV/AIDS-Related Mental Health - Depression is not associated with HIV disease status

Immunodeficiency - Natural killer cell-mediated cytotoxicity spawns liver failure

Malaria Drugs - HIV-1 protease inhibitors have antimalarial activity

Philanthropy - New HIV/AIDS collaboration launched in Kenya

Sociology Research - Many health workers in Nigeria discriminate against patients with HIV/AIDS

Tuberculosis - Recurrent tuberculosis in HIV-infected children is common in a high-burden TB setting

Virology - HIV and hepatitis C virus infection elicit similarities in natural killer cells

Virology - Liver enzyme flares require scrutiny in HIV-HCV coinfected patients beginning therapy

Virology - Rab9 GTPase required for HIV-1, filovirus and measles virus replication

Virology - Researchers publish new studies and findings in the area of virology

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