HIV/AIDS Drug Resistance
Reverse transcriptase inhibitors act together to increase HIV-1 mutation frequencies
Published in AIDS Weekly, November 14th, 2005
According to recent research published in the Journal of Virology, "The development of antiviral drug resistance is an important problem in the treatment of human immunodeficiency virus type I (HIV-1) infection. Potent antiretroviral therapy is currently used for treatment, and typically consists of at least two reverse transcriptase (RT) inhibitors."
"We have previously reported that both drugs and drug-resistant RT mutants can increase virus mutation frequencies. To further assess the contributions of nucleoside RT inhibitors (NRTIs), nonnucleoside RT...
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Source: AIDS Weekly (2005-11-14)
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