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HIV/AIDS Transmission

CD8 cell presence in semen does not correlate with levels of HIV-1 RNA shedding

Published in AIDS Weekly, December 5th, 2005

The presence of CD8 cells in the semen does not correlate with levels of HIV-1 RNA shedding.

"Sexual contact with HIV-infected semen is a major driving force behind the global HIV pandemic. Little is known regarding the immune correlates of virus shedding in this compartment, although HIV-1-specific CD8+ T cells are present in semen," researchers in Canada report.

"We collected blood and semen from 27 chronically HIV-infected, therapy-naive men without common sexually transmitted infections or urethral inflammation and measured HIV-1 RNA viral load and cytokine/chemokine levels in both compartments," said P.M. Sheth and colleagues at the University...

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