Vaccine Vector
Conditional lethality yields new vaccine strain of Listeria monocytogenes
Published in AIDS Weekly, December 5th, 2005
"Listeria monocytogenes is a Gram-positive intracellular pathogen that can enter phagocytic and nonphagocytic cells and colonize their cytosols. Taking advantage of this property to generate an intracellular vaccine delivery vector, we previously described a mutant strain of L. monocytogenes, Delta dal Delta dat, which is unable to synthesize cell wall by virtue of deletions in two genes (dal and dat) required for D-alanine synthesis," scientists writing in the journal Infection and Immunity report.
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Source: AIDS Weekly (2005-12-05)
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