HIV/AIDS Vaccines
Findings advance knowledge in HIV/AIDS vaccines research
Published in AIDS Weekly, December 12th, 2005
Study 1: HIV-1 envelope pseudotyped viral vectors and infectious molecular clones expressing the same envelope glycoprotein have a similar neutralization phenotype, but culture in peripheral blood mononuclear cells is associated with decreased neutralization.
"Recombinant lentiviral vectors pseudotyped with heterologous HIV-1 envelope glycoproteins allow rapid and accurate measurement of antibody-mediated HIV-1 neutralization. However, the neutralization phenotypes of envelope pseudoviruses have not been directly compared to isogenic replication competent...
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Source: AIDS Weekly (2005-12-12)
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