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HIV/AIDS-Related Infection

Cervicovaginal secretions contribute to resistance to herpes simplex infection in HIV/AIDS

Published in AIDS Weekly, December 19th, 2005

Cervicovaginal secretions contribute to innate resistance to herpes simplex virus infection in HIV/AIDS.

"Defining and preserving the innate antiviral activity found in cervicovaginal secretions is critical. Cervicovaginal lavage (CVL) samples were obtained from 20 healthy women and evaluated for anti-herpes simplex virus (HSV) activity," scientists in the United States report.

According to M. John and colleagues at the City University of New York, "CVL samples reduced HSV-2 yields by 23-fold (median), and the anti-HSV activity of CVL samples correlated with the concentration of human neutrophil peptides (HNP) -1 -3."

"Both CVL...

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