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AIDS Weekly

Susan Hasty, Publisher

Table of Contents . . . January 2nd, 2006

Non-Subscriber - Summaries Only

Related Areas: Other Issues in AIDS Weekly | Other Publications

Disease Associations - HIV-infected nonimmune adults are at increased risk of severe malaria

HIV/AIDS HAART - Replication-competent HIV persists in patients with uninterrupted HAART

HIV/AIDS Research - Health Canada grants approval for first-in-man clinical trial of treatment of drug resistant HIV

HIV/AIDS Therapy - Interruptions of shorter periods are unlikely to allow restoration of mitochondrial DNA

HIV/AIDS-Related Cancer - HIV-1 disease length and not immune status is a risk factor for anal carcinoma development

Diet & Nutrition - Trial final results show Resurgex reduces oxidative stress and enhances performance

Disease Associations - HIV/AIDS does not influence circulating leukocyte counts during measles infection

Disease Associations - HIV/TB coinfected donors have increased IL-4 and IFN-gamma in whole blood and lung lavage fluid

Drug Delivery - Artificial cell microcapsules overcome oral delivery problems of live bacterial cells

Drug Resistance - Research company discontinues exploratory open-label phase II trial with TMC125

Employee Health - New Best Practice AIDS Standard for corporate AIDS programs established

Enterocytozoon Bieneusi - Antibody-based fluorescence assay correlates with PCR for E. bieneusi spore detection

Facilities - Diagnostic technology company completes CE Mark facilities inspection

Feline Immunodeficiency Virus - Feline immunodeficiency virus gp36 ectodomain has been characterized

HIV/AIDS Adverse Drug Reaction - Aortic stiffness increased in HIV/AIDS patients receiving protease inhibitors

HIV/AIDS Adverse Drug Reaction - Neuropsychiatric side effects greater in HIV/AIDS patients treated with efavirenz

HIV/AIDS Adverse Drug Reaction - Pharmacotherapy in HIV/AIDS patients with cardiovascular symptoms is complex

HIV/AIDS Adverse Drug Reaction - Step-wise intervention effectively manages nelfinavir-associated diarrhea

HIV/AIDS Behavioral Medicine - Risk behavior odds among HIV-infected persons are higher in homeless populations

HIV/AIDS Diagnosis - Oral lesions are indicators of HIV infection among dental patients in Nigeria

HIV/AIDS Diagnostics - Orasure Technologies selects distributor in Singapore for HIV Antibody Test

HIV/AIDS Drug Adherence - Brief HAART adherence intervention by healthcare providers helps maintain adequate drug adherence

HIV/AIDS Drug Adherence - Self-reported HAART adherence and saquinavir AUC predict virologic response

HIV/AIDS Drug Compliance - HAART compliance predicts virologic failure in HIV/AIDS patients

HIV/AIDS Drug Development - 2F5 epitope is helical in the HIV-1 entry inhibitor T-20

HIV/AIDS Drug Development - Crowding agents mimic the crowded environment inside the HIV-1 virion

HIV/AIDS Drug Development - Metallacarboranes are specific and potent inhibitors of HIV protease

HIV/AIDS Drug Development - Sugar-binding proteins inhibit dendritic cell HIV-1 infection

HIV/AIDS Encephalitis - Macrophage-induced inflammation affects neuronal development in HIV-1 encephalitis

HIV/AIDS Epidemiology - AIDS triples the mortality of adults aged 25-44 years in Pointe-Noire

HIV/AIDS Genetic Evolution - Multiple HIV-1 provirus copies per infected cell and recombination act in synergy

HIV/AIDS HAART - Failures of lopinavir/ritonavir monotherapy can be successfully reinduced

HIV/AIDS HAART - Lopinavir/ritonavir is safe and effective in pretreated HIV-infected children

HIV/AIDS HAART - Protease inhibitors block adipocyte differentiation independently of lamin A/C

HIV/AIDS HAART - Recombination differentially affects drug resistance mutation rates

HIV/AIDS Knowledge - Risk perception and knowledge predicts willingness to provide care for HIV/AIDS patients

HIV/AIDS Mortality - Uninfected children born to advanced HIV mothers are at high risk of mortality and morbidity

HIV/AIDS Neurology - Thinning of the cerebral cortex HIV/AIDS reflects CD4 cell decline

HIV/AIDS Pathogenesis - Association of HIV-1 gag with membrane does not require highly basic sequences in the nucleocapsid

HIV/AIDS Pathogenesis - Growth inhibition by HIV Vpr occurs independently of intracellular localization in yeast

HIV/AIDS Pathogenesis - HIV-1 Tat upregulates IL-6 and IL-8 expression in breast cancer cells

HIV/AIDS Pathogenesis - HIV-1 can establish latent infection in resting CD4 cells in absence of activating stimuli

HIV/AIDS Pathogenesis - Histone deacetylase 6 regulates HIV-1 infection

HIV/AIDS Pathogenesis - NK cells may have a role in host defense against HIV infection and replication

HIV/AIDS Pathogenesis - Pathogenic simian immunodeficiency syndrome infection does not correlate with viral load

HIV/AIDS Pathogenesis - R5 HIV-1 has enhanced replication over X4 HIV-1

HIV/AIDS Pediatrics - Over the first 2 years of life, HIV-infected children show decline in mental functioning

HIV/AIDS Prevention - Postexposure prophylaxis is not completely effective in preventing HIV infection

HIV/AIDS Research - Disclosure of eligibility criteria in publications enhances applicability of findings

HIV/AIDS Research - U.S. NIAID awards $22.75 million contract to expand AAV-based HIV vaccine program

HIV/AIDS Research - U.S. NIH awards $32 million contract for ongoing HIV vaccine research

HIV/AIDS Screening - Targeting chronically ill populations for HIV treatment has short-term benefits in cost savings

HIV/AIDS Therapy - Bayesian model predicts CD4 cell count trajectory variation among long-term HAART patients

HIV/AIDS Therapy - HAART interruption is a viable option when nadir CD4 cell counts are >250 cells/mm3

HIV/AIDS Therapy - HIV fusion inhibitors have been developed to battle AIDS

HIV/AIDS Therapy - Imiquimod and CpG ODN induce antiviral cytokines but do not prevent vaginal SIV

HIV/AIDS Therapy - Non-nucleoside reverse transcriptase inhibitor has anti-HIV activity

HIV/AIDS Therapy - Topical microbicide prevents and/or treats oculo-genital adenovirus/HIV infections

HIV/AIDS Therapy - ZFN-modified cells reported to be resistant to HIV infection

HIV/AIDS Transmission - HIV-1-specific CD8+ T cell responses are factors in viral evolution in mothers/infants

HIV/AIDS Vaccine - Costimulation with CD80 and CD137L enhances HIV-specific CD8 T cell responses

HIV/AIDS Vaccine - Negative binomial regression was used to confirm IL-12 adjuvant activity

HIV/AIDS Vaccine - Probes can help development of Fab-based anti-HIV-1 therapeutics

HIV/AIDS-Associated Pulmonary Hypertension - Pulmonary hypertension incidence 1,000 times higher in HIV patients compared to general population

HIV/AIDS-Related Infection -  Cryptococcus gattii is highly prevalent among AIDS patients in southern California

HIV/AIDS-Related Lipodystrophy - Lipodystrophy in HIV/AIDS resembles the metabolic syndrome in uninfected persons

Hepatitis C Virus - Hepatitis C virus found in the semen of men coinfected with HIV-1

Hepatitis C Virus - Hepatitis C-associated autoimmunity rarely involves clinical manifestations in HIV coinfection

Kaposi Sarcoma-Associated Herpesvirus - KSHV K8 beta blocks K8 alpha-CDK2 interaction

Kaposi Sarcoma-Associated Herpesvirus - KSHV latency established and maintained in B cells

Malaria - Study explored immunological interactions between HIV and malaria

Mycobacterium Tuberculosis - MTB PPE55 may differentiate between latent and subclinical tuberculosis infection

Personnel - Lentiviral vector-focused research, development company appoints management team

Pharmaceutical Research - Survey shows health partnerships formed since 2000 helped up to 539 million people

Prison Health - Incarceration and race disparities in U.S. HIV rates is the focus of a new study

Research Funding - U.S. government grant to fund novel HIV therapy research

Tuberculosis - Diagnostics company completes successful test of TB test kit in the Republic of Ukraine

Vaccine Vector - Recombinant poxviruses were used as mucosal vaccine vectors

Virology - Viruses circumventing and/or inhibit key cellular events required for survival

Water Contamination - Control strategies are proposed to lower environmental mycobacteria in drinking water

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