HIV/AIDS Pathogenesis
Histone deacetylase 6 regulates HIV-1 infection
Published in AIDS Weekly, January 2nd, 2006
"Efficient human immunodeficiency virus (HIV)-1 infection depends on multiple interactions between the viral gp41/gp120 envelope (Env) proteins and cell surface receptors. However, cytoskeleton-associated proteins that modify membrane dynamics may also regulate the formation of the HIV-mediated fusion pore and hence viral infection," scientists in Spain report.
"Because the effects of HDAC6-tubulin deacetylase on cortical alpha-tubulin regulate cell migration and immune synapse organization," the authors said, "we explored the possible role of HDAC6 in HIV-1-envelope-mediated cell fusion and...
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Source: AIDS Weekly (2006-01-02)
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