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HIV/AIDS HAART

HAART associated with life-threatening maternal and fetal macrocytic anemia

Published in AIDS Weekly, January 9th, 2006

Lamivudine and zidovudine was associated with life-threatening maternal and fetal macrocytic anemia.

According to a recent report from the United States, "Antiretroviral therapy is recommended for human immunodeficiency virus (HIV)-infected patients during pregnancy to reduce the vertical transmission to the newborn. Complications from this therapy are uncommon."

"A 38-year-old HIV-positive pregnant woman was treated with lamivudine and zidovudine. At 28 weeks of gestation, her hemoglobin had fallen to 4.6 g/dL with a mean corpuscular volume (MCV) of 126 mcm.

"At 36 weeks the fetal biophysical profile was abnormal. A pale hydropic...

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