Published in AIDS Weekly, January 16th, 2006
Study 1: HIV-1 Env fusion is regulated by a membrane-interactive domain in the gp41 cytoplasmic tail.
According to recent research from the United States, "Truncation of the human immunodeficiency virus (HIV) or simian immunodeficiency virus (SIV) gp41 cytoplasmic tail (CT) can modulate the fusogenicity of the envelope glycoprotein (Env) on infected cells and virions.
"However, the CT domains involved and the underlying mechanism responsible for this 'inside-out' regulation of Env function are unknown."
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