Published in AIDS Weekly, January 23rd, 2006
According to recent research from the United States, "The accessory human immunodeficiency virus type I (HIV-1) protein Nef activates the autophosphorylation activity of p21-activated kinase 2 (PAK2). Merlin, a cellular substrate of PAK2, is homologous to the ezrin-radixin-moesin family and plays a critical role in Rac signaling."
"To assess the possible impact on host cell metabolism of Nef-induced PAK2 activation, we investigated the phosphorylation of merlin in Nef expressing cells. [We] report that Nef induces merlin phosphorylation in multiple cell lines independently...
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