HIV/AIDS Pathogenesis
PAK2 activation by HIV-1 Nef induces merlin phosphorylation
Published in AIDS Weekly, January 23rd, 2006
According to recent research from the United States, "The accessory human immunodeficiency virus type I (HIV-1) protein Nef activates the autophosphorylation activity of p21-activated kinase 2 (PAK2). Merlin, a cellular substrate of PAK2, is homologous to the ezrin-radixin-moesin family and plays a critical role in Rac signaling."
"To assess the possible impact on host cell metabolism of Nef-induced PAK2 activation, we investigated the phosphorylation of merlin in Nef expressing cells. [We] report that Nef induces merlin phosphorylation in multiple cell lines independently...
Want to see the full article?
We're a pay-per-view site for premium content. If you'd like to purchase this article, it's only $3.00.
Welcome to NewsRx!
Learn more about a six-week, no-risk free trial of AIDS Weekly
Source: AIDS Weekly (2006-01-23)
More Articles from AIDS Weekly
- Genetics & Genomics
South African GB virus C genotypes inhibit HIV replication - HIV/AIDS Drug Adherence
Obtaining refills via pill organizers dispensed by pharmacist improves HAART adherence - HIV/AIDS Drug Interaction
Didenosine EC AUC is increased when dosed along with tenofovir DF - HIV/AIDS Pathogenesis
HIV-1 VPR protects against lethal superantigen challenge while maintaining T cell levels - HIV/AIDS Pathogenesis
Tat-specific CD8 cells suppress SIV replication more effectively than Gag-specific cells - Adolescent Health
Study supports goal of abstinence but is critical of abstinence-only programs - More from this issue of AIDS Weekly
NewsRx is Social
Follow us on your favorite social network by clicking on a button below:
Top Medical Newsletters
Awards
Best Health/Healthcare Content, 2012
Best Health/Healthcare Content, 2011
Best e-Business Site, 2010
Best e-Business Site, 2009
Best e-Business Site, 2008
Best e-Business Site, 2007
Best e-Business Site, 2006
Best Healthcare Content, 2005
Best Overall Internet Site, 2005
Best Interactive Site, 2005
Facts & Stats
NewsRx also is available at LexisNexis, Gale, ProQuest, Factiva, Dialog, Thomson Reuters, NewsEdge, and Dow Jones.
- Google 2010 PageRank: #2 Among Top Health News and Media Publications
- Google 2010 PageRank: #2 Among Top Science Publications in Biology/Physiology
- Google 2010 PageRank: #2 Among Top News and Media for the Business of Pharmaceuticals
- Amazon's Alexa 2010 PageRank: #2 News and Media Site for the Pharmaceutical Industry
