HIV/AIDS Pathogenesis
Hsp40 necessary for HIV-1 Nef-mediated enhancement of viral gene expression and replication
Published in AIDS Weekly, January 30th, 2006
According to recent research from India, "The human immunodeficiency virus-1 (HIV-1) Nef protein, originally identified as a negative factor, has now emerged as one of the most important viral proteins necessary for viral pathogenesis and disease progression.
"Nef has been also implicated in viral infectivity and replication, however, the molecular mechanism of Nef-induced viral gene expression and replication is not clearly understood."
"Although involvement of heat shock proteins in viral pathogenesis has been reported...
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Source: AIDS Weekly (2006-01-30)
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