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HIV/AIDS Vaccine

Enhanced antigenemia during chronic SIV infection may augment virus-specific immunity

Published in AIDS Weekly, January 30th, 2006

A transient period of enhanced antigenemia during chronic SIV infection may serve to augment virus-specific immunity

"In vivo depletion of CD8+ T cells results in an increase in viral load in macaques chronically infected with simian immunodeficiency virus (SlVmac239 Delta nef). [In our report], the cellular and humoral immune responses associated with this transient period of enhanced viremia in macaques infected with SIVmac239Anef were characterized," investigators in the United States report.

"Fourteen days after in vivo CD8+ T-cell depletion, two of six macaques experienced a 1-2 log10 increase in anti-gp130 and p27 antibody titers...

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