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HIV/AIDS HAART

GNB3 C825T polymorphism associated with short-term success of HAART treatment

Published in AIDS Weekly, February 6th, 2006

The GNB3 C825T polymorphism is associated with short-term success of HAART treatment.

"Analyses were based on a cohort of 55 HIV infected patients whose treatment was changed due to therapy failure. Vital load, CD4+ and CD8+ cell Counts were determined before therapy and after 8 weeks and 16-32 weeks, respectively," scientists in Germany report.

According to N.H. Brockmeyer and colleagues at Ruhr University of Bochum, "GNB3 genotyping was performed using pyrosequencing. Chemotaxis of purified CD4+ cello was quantified in a Boyden chamber using stromal cell-derived factor 1 alpha (SDF-1 alpha) as a stimulus.

"Age gender, route of...

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