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HIV/AIDS Research

Pharma companies select two next generation HIV fusion inhibitor drug candidates for development

Published in AIDS Weekly, February 13th, 2006

Roche and Trimeris, Inc. (TRMS) announced the selection of two next-generation fusion inhibitor peptides for codevelopment for treatment of HIV/AIDS and progression into further preclinical studies.

The peptides, TR-291144 and TR-290999, first synthesized at Trimeris, are distinct compounds derived from HR2 sequences of HIV. In connection with this event, Trimeris will receive a payment from Roche.

TR-291144 and TR-290999 are being developed with the specific goal of achieving durable suppression of HIV by increasing the potency of the molecules and raising their genetic barrier to the development of resistance. Also central to the development...

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