HIV/AIDS Drug Development
Phosphonate prodrugs more active against HIV compared to the parent PMEA
Published in AIDS Weekly, February 20th, 2006
According to recent research published in the Journal of Medicinal Chemistry, "Two new classes of lipophilic prodrugs of the antiviral active phosphonate 9-[2-phosphonomethoxyethyl] adenine (PMEA 1) have been prepared and were studied with regard to their hydrolysis properties and biological activity. A first series of compounds was prepared on the basis of the cycloSal nucleotide approach."
"Because of the surprisingly low hydrolysis stability of these cycloSal-PMEA derivatives, more stable derivatives have to be developed. Instead of using salicyl alcohol, in...
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Source: AIDS Weekly (2006-02-20)
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