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HIV/AIDS Genetics

HIV-1 RNA binding protein interacts with Dicer and functions in RNA silencing

Published in AIDS Weekly, February 27th, 2006

According to recently published research from Switzerland, human immunodeficiency virus (HIV-1) transactivating response (TAR) RNA-binding protein (TRBP), a regulator of cellular PKR and HIV-1 virus expression, interacts with Dicer and functions in RNA silencing.

"Dicer is a key enzyme involved in RNA interference (RNAi) and microRNA (miRNA) pathways. It is required for biogenesis of miRNAs and small interfering RNAs (siRNAs), and also has a role in the effector steps of RNA silencing," wrote A.D. Haase and colleagues, Friedrich Miescher Institute for Biomedical Research.

"Apart from Argonautes, no proteins are known to associate with Dicer in...

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