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HIV/AIDS Pathogenesis

LIF induced in initial stages of viral dissemination during primary HIV-1 infection

Published in AIDS Weekly, February 27th, 2006

Leukemia inhibitory factor is induced in the initial stages of viral dissemination during primary HIV-1 infection.

According to recently published research from Sweden, "Leukemia inhibitor factor (LIF) is thought to play a substantial role in protecting CD4 T cells in lymphoid tissues (LT) from infection by HIV-1.

"To investigate whether primary HIV-1 infected subjects with sustained virological control (<1000 HIV-1 RNA copies/mL plasma) postcessation antiretroviral therapy (ART) had a higher initial LIF response during primary HIV-1 infection (PHI) as compared with those individuals who did not achieve a similar control (>9000 HIV-1 RNA...

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