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HIV/AIDS Pharmaceutical Research

Extended-release clarithromycin well tolerated and bioequivalent to IR formulation

Published in AIDS Weekly, February 27th, 2006

Extended-release clarithromycin is well tolerated and bioequivalent to the immediate-release formulation for Mycobacterium avium complex infection in AIDS patients.

"Clarithromycin is a key agent in effective antimycobacterial therapy and prophylaxis for AIDS-related disseminated Mycobacterium avium complex (dMAC) infection. Immediate-release (IR) clarithromycin tablets are dosed at 500 mg bid for these indications," scientists writing in the journal HIV Clinical Trials report.

According to the authors, "A new extended-release (ER) tablet of clarithromycin has been developed and approved at a dosing interval of once every 24...

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