HIV/AIDS Pathogenesis
Immature dendritic cell-derived exosomes can mediate HIV-1 trans infection
Published in AIDS Weekly, March 6th, 2006
"Immature dendritic cells (DCs) capture HIV type 1 (HIV-1) and can transmit captured virus particles to T cells. In this report, we show that HIV-1 particles captured by DCs can be transmitted to T cells by exocytosis without de novo infection," scientists in the United States report.
According to the authors, "Captured HIV-1 particles were rapidly endocytosed to tetraspan protein (CD9, CD63)-positive endocytic compartments that were reminiscent of multivesicular endosomal bodies.
"Furthermore, some of the endocytosed virus particles were constitutively...
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Source: AIDS Weekly (2006-03-06)
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