HIV/AIDS Pathogenesis
NF-kappaB p50-histone deacetylase 1 complexes constitutively bind latent HIV LTR
Published in AIDS Weekly, March 6th, 2006
"Cells latently infected with HIV represent a currently insurmountable barrier to viral eradication in infected patients. Using the J-Lat human T-cell model of HIV latency, we have investigated the role of host factor binding to the kappaB enhancer elements of the HIV long terminal repeat (LTR) in the maintenance of viral latency," scientists in the United States report.
According to S.A. Williams and colleagues at the University of California, San Francisco, "We show that NF-kappaB p50-HDAC1 complexes constitutively bind the...
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Source: AIDS Weekly (2006-03-06)
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