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HIV/AIDS Vaccine

Antibody responses elicited by HIV glycoproteins are characterized

Published in AIDS Weekly, March 20th, 2006

Scientists characterize antibody responses elicited by human immunodeficiency virus type 1 primary isolate trimeric and monomeric envelope glycoproteins in selected adjuvants in a recent issue of the Journal of Virology.

According to recent research from the United States and Belgium, "We previously reported that soluble, stable YU2 gp140 trimeric human immunodeficiency virus type I (HIV-1) envelope glycoprotein immunogens could elicit improved breadth of neutralization against HIV-1 isolates compared to monomeric YU2 gp120 proteins. In this guinea pig immunization study, we sought to extend these data and determine if adjuvant could quantitatively or...

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