HIV/AIDS Pathogenesis
HIV-1 gp120 induces NFAT nuclear translocation in resting CD4+ cells
Published in AIDS Weekly, April 3rd, 2006
"The replication of human immunodeficiency virus (HIV) in CD4+ T-cells is strongly dependent upon the state of activation of infected cells. Infection of suboptimally activated cells is believed to play a critical role in both the transmission of virus and the persistence of CD4+ T-cell reservoirs," scientists writing in the journal Virology report.
According to the authors, "There is accumulating evidence that HIV can modulate signal-transduction pathways in a manner that may facilitate replication in such cells. We previously demonstrated that HIV gp120 induces virus...
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Source: AIDS Weekly (2006-04-03)
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