HIV/AIDS Vaccine
CD40 and GITR ligands act as adjuvants for HIV DNA vaccines
Published in AIDS Weekly, April 3rd, 2006
"For use in humans, human immunodeficiency virus (HIV) DNA vaccines may need to include immunostimulatory adjuvant molecules. CD40 ligand (CD40L), a member of the tumor necrosis factor (TNF) superfamily (TNFSF), is one candidate adjuvant, but it has been difficult to use because it is normally expressed as a trimeric membrane molecule. Soluble trimeric forms of CD40L have been produced, but in vitro data indicate that multimeric, many-trimer forms of soluble CD40L are more active," researchers in the United States report.
"This...
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Source: AIDS Weekly (2006-04-03)
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