Chronic Viral Infection
In chronic viral infection, blocking antibodies restore function in exhausted CD8 cells
Published in AIDS Weekly, April 17th, 2006
According to recent research published in the journal Nature, "Functional impairment of antigen-specific T cells is a defining characteristic of many chronic infections, but the underlying mechanisms of T-cell dysfunction are not well understood."
"To address this question, we analyzed genes expressed in functionally impaired virus-specific CD8 T cells present in mice chronically infected with lymphocytic choriomeningitis virus (LCMV), and compared these with the gene profile of functional memory CD8 T cells," wrote .L. Barber and colleagues at Emory...
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Source: AIDS Weekly (2006-04-17)
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