HIV/AIDS Pathogenesis

Researchers detail new studies and findings in the area of HIV/AIDS pathogenesis

Published in AIDS Weekly, April 24th, 2006

HIV/AIDS pathogenesis data are the focus of recent research from Japan, India and the United States.

Study 1: Estrogen stimulates HIV-1 transcription.

"Gene expression from human immunodeficiency virus (HIV) provirus is a crucial step for the viral replication. Here we examined a potential role of 17 beta-estradiol (E2) in HIV-1 transcription," investigators in Japan report.

According to D. Katagiri and colleagues at Nagoya City University, "Transient luciferase expression studies revealed that E2 activated HIV-LTR reporter gene in HEK293 cells when the cells were cotransfected with estrogen receptor alpha (ERU) but not ER beta...

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Source: AIDS Weekly (2006-04-24)

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