HIV/AIDS Prognostic Indicators
Statistical model predicts HAART response from RT and protease amino acid sequence data
Published in AIDS Weekly, April 24th, 2006
According to recent research from the United States, "Genotype-phenotype modeling problems are often overcomplete, or ill-posed, since the number of potential predictors-genes, proteins, mutations and their interactions-is large relative to the number of measured outcomes.
"Such datasets can still be used to train sparse parameter models that generalize accurately, by exerting a principle similar to Occam's Razor: When many possible theories can explain the observations, the most simple is most likely to be correct. We apply this philosophy...
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Source: AIDS Weekly (2006-04-24)
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