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HIV/AIDS Vaccine

Polyvalent DNA prime/protein boost HIV-1 vaccine is immunogenic and safe

Published in AIDS Weekly, April 24th, 2006

A polyvalent DNA prime/protein boost HIV-1 vaccine lacks signs of toxicity and DNA integration.

According to recent research from the United States, "A toxicity and immunogenicity study, evaluating the safety of a polyvalent DNA prime/protein boost HIV-1 vaccine (DP6-001), was examined in rabbits.

"Animals were primed with a cocktail of six different DNA plasmids expressing five HIV-1 env genes and one gag gene followed by boosting with five gp120 proteins homologous to the DNA vaccines."

"The vaccine was shown to be immunogenic as evident from the induction of high-titered anti-Env and anti-Gag antibodies. There was an absence of...

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