HIV/AIDS Vaccines
Research add new data to HIV/AIDS vaccines body of knowledge
Published in AIDS Weekly, April 24th, 2006
Study 1: Multimeric soluble CD40 ligand and GITR ligand act as adjuvants for human immunodeficiency virus DNA vaccines.
"For use in humans, human immunodeficiency virus (HIV) DNA vaccines may need to include immunostimulatory adjuvant molecules. CD40 ligand (CD40L), a member of the tumor necrosis factor (TNF) superfamily (TNFSF), is one candidate adjuvant, but it has been difficult to use because it is normally expressed as a trimeric membrane molecule. Soluble trimeric forms of CD40L have been produced, but in vitro data indicate that multimeric, many-trimer...
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Source: AIDS Weekly (2006-04-24)
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