Neuroscience
Cocaine-mediated enhancement of hippocampal Tat toxicity is related to induced oxidative stress
Published in AIDS Weekly, April 24th, 2006
"It is becoming widely accepted that psychoactive drugs can significantly alter the progression of neuropathological changes in the HIV-infected brain. The use of cocaine can aggravate the neurotoxic effects of HIV-1 proteins such as HIV-1 transactivating protein Tat and virus' envelope protein gp120," wrote M.Y. Aksenov and colleagues, University of South Carolina.
They continued, "HIV-1 Tat is believed to play an important role in pathogenesis of HIV dementia (HAD). Tat is neurotoxic and a constantly...
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Source: AIDS Weekly (2006-04-24)
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