HIV/AIDS Evolution
Persistent immune activation reduces its regenerative capacity and facilitates HIV evolution
Published in AIDS Weekly, May 1st, 2006
"Upon transmission to a new host, HIV targets CCR5+CD4+ effector memory T cells, resulting in acute, massive depletion of these cells from mucosal effector sites.
"This depletion does not initially compromise the regenerative capacity of the immune system because naive and most central memory T cells are spared," researchers in the United States report.
According to Z. Grossman and colleagues at the U.S. National Institutes of Health, "Here, we discuss evidence suggesting that frequent activation of these spared cells during the chronic...
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Source: AIDS Weekly (2006-05-01)
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