HIV/AIDS Pathogenesis
Viral fitness contributes substantially to evolutionary pattern of thymidine analog mutations
Published in AIDS Weekly, May 1st, 2006
"All currently recommended antiretroviral therapy protocols employ reverse transcriptase inhibitors (RTIs). However, mutations within the reverse transcriptase (RT) domain can lead to resistance to these agents and treatment failure.
"The contribution of the fitness of drug-resistant species to the evolution of RTI resistance has not been elucidated despite its potential implications for therapeutic strategies," wrote investigators in the United States.
According to E. Paintsil and colleagues at Yale University, School of...
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Source: AIDS Weekly (2006-05-01)
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