HIV/AIDS Genetics & Genomics
Rate of drug resistance development may be similar for different HIV-1 subtypes
Published in AIDS Weekly, May 8th, 2006
"The genetic barrier, defined as the number of mutations required to overcome drug-selective pressure, is an important factor for the development of HIV drug resistance.
"Because of high variability between subtypes, particular HIV-1 subtypes could have different genetic barriers for drug resistance substitutions," scientists in the Netherlands report.
"This study compared the genetic barrier between subtypes using some 2000 HIV-1 sequences (>600 of non-B subtype) isolated from antiretroviral-naive patients in Europe. The genetic barrier was...
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Source: AIDS Weekly (2006-05-08)
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