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HIV Research

Immune response to HIV in the brain a "double-edged sword"

Published in AIDS Weekly, May 29th, 2006

A team of researchers at the Scripps Research Institute has shed new light on the molecular basis of problems with brain function in models chronically infected with an immune deficiency virus similar to human immunodeficiency virus (HIV), the cause of acquired immune deficiency syndrome (AIDS).

The findings may ultimately lead to new therapeutic interventions to prevent or reverse nervous system disorders in HIV-infected individuals.

Using multidisciplinary analysis that included cognitive, neurophysiologic, virologic, and molecular techniques, the team found both a low-level viral infection in the brain and immune cells that had infiltrated the...

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