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HIV/AIDS Adverse Drug Reaction

Atazanavir/ritonavir combination has fewer adverse effects than lopinavir/ritonavir

Published in AIDS Weekly, May 29th, 2006

Once-daily atazanavir/ritonavir has fewer adverse effects than twice-daily lopinavir/ritonavir in HIV/AIDS.

According to recent research from England, "In BMS Study 045, once-daily (QD) atazanavir/ritonavir (ATV/RTV) demonstrated comparable efficacy and safety to twice-daily (BID) lopinavir/ritonavir (LPV/RTV) over 48 weeks in treatment-experienced patients. Results of extended follow-up to 96 weeks are presented."

"BMS Study 045 was an open-label, randomized, multinational trial of HIV-infected patients with virologic failure on two or more prior HAART regimens designed to evaluate the efficacy and safety of ATV/RTV (300/100 mg) QD and LPV/RTV...

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