HIV/AIDS Pathogenesis
HIV-1 progression affected by nonsense mutation 428G->A in fucosyltransferase FUT2 gene
Published in AIDS Weekly, May 29th, 2006
According to recently published research from Sweden, "The human FUT2 gene encodes the alpha(1,2)fucosyltransferase that determines secretor status. Homozygous for the nonsense mutation are called nonsecretors and are unable to express histo-blood group antigens in secretions and on mucosal surfaces."
"In this study we have investigated the importance of the FUT2 fucosyltransferase activity on the progress of HIV-1 infection. Swedish blood donors (n=276), 15 long-term nonprogressors (LTNP) and 19 progressors were genotyped with respect to...
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Source: AIDS Weekly (2006-05-29)
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