HIV/AIDS
Findings from the United States and Belgium advance knowledge in HIV/AIDS research
Published in AIDS Weekly, May 29th, 2006
Study 1: The HIV Vif and Vpr proteins play key roles in T-cell cytopathicity and cell cycle arrest.
"HIV type 1 (HIV-1) can cause G2 cell cycle arrest and death of CD4+ T lymphocytes in vitro and inexorable depletion of these cells in vivo," immunologists in the United States explained. "However, the molecular mechanism of viral cytopathicity has not been satisfactorily elucidated."
"Previously, we showed that HIV-1 kills T cells by a necrotic form of cell death that requires high level expression of an integrated provirus but...
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Source: AIDS Weekly (2006-05-29)
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