Published in AIDS Weekly, May 29th, 2006
Study 1: Basic residues in the gag nucleocapsid domain are required for HIV-1 Gag-ABCE1 interaction.
According to a study from the United States, "During human immunodeficiency virus, type 1 (HIV-1) assembly, Gag polypeptides multimerize into immature HIV-1 capsids.
"The cellular ATP-binding protein ABCE1 (also called HP68 or RNase L inhibitor) appears to be critical for proper assembly of the HIV-1 capsid. In primate cells, ABCE1 associates with Gag polypeptides present in immature capsid assembly intermediates."
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